Senile hair graying: H2O2‐mediated oxidative stress affects human hair color by blunting methionine sulfoxide repair

@article{Wood2009SenileHG,
  title={Senile hair graying: H2O2‐mediated oxidative stress affects human hair color by blunting methionine sulfoxide repair},
  author={J. M. Wood and H. Decker and H. Hartmann and B. Chavan and H. Rokos and J. Spencer and S. Hasse and M. Thornton and M. Shalbaf and R. Paus and K. Schallreuter},
  journal={The FASEB Journal},
  year={2009},
  volume={23},
  pages={2065 - 2075}
}
Senile graying of human hair has been the subject of intense research since ancient times. Reactive oxygen species have been implicated in hair follicle melanocyte apoptosis and DNA damage. Here we show for the first time by FT‐Raman spectroscopy in vivo that human gray/white scalp hair shafts accumulate hydrogen peroxide (H2O2) in millimolar concentrations. Moreover, we demonstrate almost absent catalase and methionine sulfoxide reductase A and B protein expression via immunofluorescence and… Expand
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