Senile hair graying: H2O2‐mediated oxidative stress affects human hair color by blunting methionine sulfoxide repair

@article{Wood2009SenileHG,
  title={Senile hair graying: H2O2‐mediated oxidative stress affects human hair color by blunting methionine sulfoxide repair},
  author={John M. Wood and Heinz Decker and H. Hartmann and Bhaven Chavan and Hartmut Rokos and Jennifer D. Spencer and Sybille Hasse and M. J. Thornton and Mohamed Shalbaf and Ralf Paus and K U Schallreuter},
  journal={The FASEB Journal},
  year={2009},
  volume={23},
  pages={2065 - 2075}
}
Senile graying of human hair has been the subject of intense research since ancient times. Reactive oxygen species have been implicated in hair follicle melanocyte apoptosis and DNA damage. Here we show for the first time by FT‐Raman spectroscopy in vivo that human gray/white scalp hair shafts accumulate hydrogen peroxide (H2O2) in millimolar concentrations. Moreover, we demonstrate almost absent catalase and methionine sulfoxide reductase A and B protein expression via immunofluorescence and… 
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Age-induced hair graying (canities), or the age-induced loss of melanin synthesis and deposition within the hair shafts, is a noticeable and undesired sign of the aging process. Numerous mechanisms…
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Better understanding of the overtime susceptibility of melanocytes to oxidative stress at the different follicular locations might yield clues to possible therapies for the prevention and reversal of hair greying.
Premature Graying as a Consequence of Compromised Antioxidant Activity in Hair Bulb Melanocytes and Their Precursors
Intricate coordinated mechanisms that govern the synchrony of hair growth and melanin synthesis remain largely unclear. These two events can be uncoupled in prematurely gray hair, probably due to…
ABSENCE OF H2O2 BREAKDOWN IN HUMAN HAIR MEDULLA IMPLICATIONS IN FOLLICULAR MELANOGENESIS
  • A. A.
  • Biology
    International Journal of Research -GRANTHAALAYAH
  • 2018
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A new paradigm is herein introduced where the human hair medulla is excluded from H2O2 breakdown, thus inferring the absence of metabolic activity from FM.
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The effect of H2O2‐redox homeostasis on hair follicle pigmentation via tyrosinase, its substrate supply and signal transduction as well as the role of methionine sulfoxide repair via methionin sulfoxide reductases A and B (MSRA and B).
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The in vitro model of primary human scalp hair follicle melanocytes showed that ATM expression increased after incubation with the pro-oxidant hydrogen peroxide (H2O2), and the inhibition of ATM expression by chemical inhibition promoted the loss of melanocyte viability induced by oxidative stress.
Global Repigmentation Strategy of Grey Hair Follicles by Targeting Oxidative Stress and Stem Cells Protection
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This active ingredient is developed which is capable of restoring all the disrupted mechanisms and of providing hair repigmentation within only 4 months, clearly evidenced that oxidative stress is a key factor in triggering a cascade of events leading to a loss of hair pigmentation.
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It is emphasized that human greying invariably begins with the gradual decline in melanogenesis, including reduced tyrosinase activity, defective melanosome transfer and apoptosis of HFPU melanocytes, and is thus a primary event of the anagen hair bulb, not the bulge.
Blunted epidermal L‐tryptophan metabolism in vitiligo affects immune response and ROS scavenging by Fenton chemistry, part 1: epidermal H2O2/ONOO–‐mediated stress abrogates tryptophan hydroxylase and dopa decarboxylase activities, leading to low serotonin and melatonin levels
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The data point to depletion of epidermal Trp by Fenton chemistry and exclude melatonin as a relevant contributor to epidersmal redox balance and immune response in vitiligo.
Human Hair Graying is Naturally Reversible and Linked to Stress
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This work develops an approach to quantitatively profile natural graying events and their associated proteomic signatures along individual human hairs, resulting in a quantifiable physical timescale of aging and provides a new model to examine the modifiability of human aging.
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