Senile degenerative brain lesions and dementia.

  title={Senile degenerative brain lesions and dementia.},
  author={Mitsunori Morimatsu and S.-i. Hirai and Akira Muramatsu and Motoko Yoshikawa},
  journal={Journal of the American Geriatrics Society},
  volume={23 9},
In a study of senile degenerative lesions-including Alzheimer's neurofibrillary changes, senile plaques and amyloid angiopathy-the hippocampal area of the brain was examined by thioflavine T fluorescence microscopy in 146 consecutive autopsy patients over the age of 49. The incidence and quantity of neurofibrillary changes and senile plaques rose with age, and an approximate positive correlation in quantity was noted among the three kinds of degenerative change. The quantity of neurofibrillary… CONTINUE READING