Senescent stroma promotes prostate cancer progression: the role of miR-210.

  title={Senescent stroma promotes prostate cancer progression: the role of miR-210.},
  author={Maria Letizia Taddei and Lorenzo Cavallini and Giuseppina Comito and Elisa Giannoni and Marco Folini and Alberto Marini and Paolo Gandellini and Andrea Morandi and Gianfranco Pintus and Maria Rosaria Raspollini and Nadia Zaffaroni and Paola Chiarugi},
  journal={Molecular oncology},
  volume={8 8},
We focused our interest on senescent human-derived fibroblasts in the progression of prostate cancer. Hypoxic senescent fibroblasts promote prostate cancer aggressiveness by inducing epithelial to mesenchymal transition (EMT) and by secreting energy-rich compounds to support cancer cell growth. Hypoxic senescent fibroblasts additionally increase: i) the recruitment of monocytes and their M2-macrophage polarization, ii) the recruitment of bone marrow-derived endothelial precursor cells… CONTINUE READING
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