Senescent stroma promotes prostate cancer progression: The role of miR‐210

  title={Senescent stroma promotes prostate cancer progression: The role of miR‐210},
  author={Maria Letizia Taddei and L. Cavallini and G. Comito and E. Giannoni and M. Folini and Alberto Marini and P. Gandellini and Andrea Morandi and G. Pintus and M. Raspollini and N. Zaffaroni and P. Chiarugi},
  journal={Molecular Oncology},
  • Maria Letizia Taddei, L. Cavallini, +9 authors P. Chiarugi
  • Published 2014
  • Medicine, Biology
  • Molecular Oncology
  • We focused our interest on senescent human‐derived fibroblasts in the progression of prostate cancer. Hypoxic senescent fibroblasts promote prostate cancer aggressiveness by inducing epithelial to mesenchymal transition (EMT) and by secreting energy‐rich compounds to support cancer cell growth. Hypoxic senescent fibroblasts additionally increase: i) the recruitment of monocytes and their M2‐macrophage polarization, ii) the recruitment of bone marrow‐derived endothelial precursor cells… CONTINUE READING
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