Senescent hepatocyte secretion of matrix metalloproteinases is regulated by nuclear factor-κB signaling.

@article{Zang2017SenescentHS,
  title={Senescent hepatocyte secretion of matrix metalloproteinases is regulated by nuclear factor-κB signaling.},
  author={Jinfeng Zang and Min Sha and Chi Zhang and Jun Ye and Kezhi Zhang and Junye Gao},
  journal={Life sciences},
  year={2017},
  volume={191},
  pages={205-210}
}
AIMS Cellular senescence and matrix metalloproteinases (MMPs) play an important role in liver diseases. The source and regulating factors of MMPs in senescent hepatocytes are not known. We investigated whether senescent hepatocytes secreted MMPs and if this was regulated by nuclear factor (NF)-κB. MATERIALS AND METHODS The TGF-α transgenic mouse hepatocyte line AML12 was treated with H2O2 to induce senescence. NF-κB signaling was examined by Western blotting and luciferase reporter assays… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS