Senescent fibroblasts resist apoptosis by downregulating caspase-3

@article{Marcotte2004SenescentFR,
  title={Senescent fibroblasts resist apoptosis by downregulating caspase-3},
  author={Richard A. Marcotte and Chantale Lacelle and Eugenia Wang},
  journal={Mechanisms of Ageing and Development},
  year={2004},
  volume={125},
  pages={777-783}
}
In replicative senescence, cells undergo permanent exit from cell cycle traverse; this is traditionally thought to occur at the end of a culture's in vitro life span, after serial passaging. In general, the checkpoint for replicative senescence is found at the G(1)/S border, controlled by the modulation of a battery of proteins, typified by gaining inhibitors of cell cycle traverse, such as cyclin-dependent kinases or RB hyperphosphorylation, and losing pro-proliferation gene expressions such… CONTINUE READING
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