Senescent cells spread the word: non-cell autonomous propagation of cellular senescence.

@article{Tasdemir2013SenescentCS,
  title={Senescent cells spread the word: non-cell autonomous propagation of cellular senescence.},
  author={Nilgun Tasdemir and Scott W Lowe},
  journal={The EMBO journal},
  year={2013},
  volume={32 14},
  pages={1975-6}
}
Senescence has long been considered a cell autonomous arrest programme restricting the propagation of damaged cells in tissues. Now there is accumulating evidence that senescent cells can communicate with their environment. In a recent report by Gil and colleagues (Acosta et al, 2013), it now seems senescence can be transmitted in a paracrine fashion in several in vitro and in vivo contexts. In addition to broadening our understanding of the biology of senescence, these new findings may have… CONTINUE READING
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