Senescent cells: SASPected drivers of age-related pathologies

Abstract

The progression of physiological ageing is driven by intracellular aberrations including telomere attrition, genomic instability, epigenetic alterations and loss of proteostasis. These in turn damage cells and compromise their functionality. Cellular senescence, a stable irreversible cell-cycle arrest, is elicited in damaged cells and prevents their… (More)
DOI: 10.1007/s10522-014-9529-9

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