Senescent cells: Living or dying is a matter of NK cells

  title={Senescent cells: Living or dying is a matter of NK cells},
  author={F. Antonangeli and A. Zingoni and A. Soriani and A. Santoni},
  journal={Journal of Leukocyte Biology},
  pages={1275 - 1283}
  • F. Antonangeli, A. Zingoni, +1 author A. Santoni
  • Published 2019
  • Biology, Medicine
  • Journal of Leukocyte Biology
  • NK cells are lymphocytes of the innate immune system, which are able to deal promptly with stressed cells. Cellular senescence is a cell stress response leading to cell cycle arrest that plays a key role during tissue homeostasis and carcinogenesis. In this review, how senescent cells trigger an immune response and, in particular, the ability of NK cells to recognize and clear senescent cells are discussed. Special attention is given to the NK cell‐mediated clearance of senescent tumor cells… CONTINUE READING
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