Senescent cells: Living or dying is a matter of NK cells

@article{Antonangeli2019SenescentCL,
  title={Senescent cells: Living or dying is a matter of NK cells},
  author={Fabrizio Antonangeli and Alessandra Zingoni and Alessandra Soriani and Angela Santoni},
  journal={Journal of Leukocyte Biology},
  year={2019},
  volume={105},
  pages={1275 - 1283}
}
NK cells are lymphocytes of the innate immune system, which are able to deal promptly with stressed cells. Cellular senescence is a cell stress response leading to cell cycle arrest that plays a key role during tissue homeostasis and carcinogenesis. In this review, how senescent cells trigger an immune response and, in particular, the ability of NK cells to recognize and clear senescent cells are discussed. Special attention is given to the NK cell‐mediated clearance of senescent tumor cells… 
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References

SHOWING 1-10 OF 138 REFERENCES
Immunosurveillance of senescent cells: the bright side of the senescence program
TLDR
Current advances in knowledge of the mechanisms underlying specific immune-mediated elimination of senescent cells are summarized.
Granule exocytosis mediates immune surveillance of senescent cells
TLDR
It is shown that granule exocytosis, but not death-receptor-mediated apoptosis, is required for NK-cell-mediated killing of senescent cells, and this results provide new insights into the immune surveillance of senescence and reveal how granuleExocytotic has a protective role against liver fibrosis.
NKG2D ligands mediate immunosurveillance of senescent cells
TLDR
The results provide new insights into the mechanisms regulating the expression of immune ligands in senescent cells and reveal the importance of NKG2D receptor-ligand interaction in protecting against liver fibrosis.
Immunosenescence of Human Natural Killer Cells
TLDR
The expression of CD57, a marker of highly differentiated NK cells, is increased in the elderly; this supports the notion that a remodeling process of NK cell subsets occurs in aging with a gradual decrease in more immature CD56bright NK cells and an increase in highly differentiated CD56dim CD57+ NK cells.
Natural Killer Cell Response to Chemotherapy-Stressed Cancer Cells: Role in Tumor Immunosurveillance
TLDR
Recent advances in chemotherapy-mediated cellular stress pathways able to stimulate NK cell effector functions are reviewed, addressing how these cytotoxic lymphocytes sense and respond to different types of drug-induced stresses contributing to anticancer activity.
Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL
TLDR
The finding that senescent cells can be eliminated pharmacologically paves the way to new strategies for the treatment of age-related pathologies.
Immunosenescence: limitations of natural killer cell-based cancer immunotherapy
TLDR
The effect of both age and cancer may act synergistically to diminish NK cell-mediated tumour immunosurveillance and the effect of immunosenescence should be considered to improve the efficiency of cancer immunotherapy.
NK cells and interferons.
Type 1 interferons contribute to the clearance of senescent cell
TLDR
The role of IFN in protecting the multi-cellular host from accumulation of damaged senescent cells and potential significance of this mechanism in human cancers is discussed.
Senescence and apoptosis: dueling or complementary cell fates?
TLDR
The advantages that the senescence program may have over apoptosis as a tumor protective mechanism, as well as non‐neoplastic functions that may have contributed to its evolution are discussed.
...
1
2
3
4
5
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