Senescent Vascular Smooth Muscle Cells Drive Inflammation Through an Interleukin-1α–Dependent Senescence-Associated Secretory Phenotype

@inproceedings{Gardner2015SenescentVS,
  title={Senescent Vascular Smooth Muscle Cells Drive Inflammation Through an Interleukin-1α–Dependent Senescence-Associated Secretory Phenotype},
  author={Sarah E. Gardner and Melanie Humphry and Martin R. Bennett and Murray C. H. Clarke},
  booktitle={Arteriosclerosis, thrombosis, and vascular biology},
  year={2015}
}
OBJECTIVE Vascular smooth muscle cells (VSMCs) that become senescent are both present within atherosclerotic plaques and thought to be important to the disease process. However, senescent VSMCs are generally considered to only contribute through inaction, with failure to proliferate resulting in VSMC- and collagen-poor unstable fibrous caps. Whether senescent VSMCs can actively contribute to atherogenic processes, such as inflammation, is unknown. APPROACH AND RESULTS We find that senescent… CONTINUE READING
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