Senescence-messaging secretome: SMS-ing cellular stress

@article{Kuilman2009SenescencemessagingSS,
  title={Senescence-messaging secretome: SMS-ing cellular stress},
  author={Thomas Kuilman and Daniel S Peeper},
  journal={Nature Reviews Cancer},
  year={2009},
  volume={9},
  pages={81-94}
}
Oncogene-induced cellular senescence constitutes a strong anti-proliferative response, which can be set in motion following either oncogene activation or loss of tumour suppressor signalling. It serves to limit the expansion of early neoplastic cells and as such is a potent cancer-protective response to oncogenic events. Recently emerging evidence points to a crucial role in oncogene-induced cellular senescence for the 'senescence-messaging secretome' or SMS, setting the stage for cross-talk… CONTINUE READING

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SHOWING 1-10 OF 162 REFERENCES

Insulin-like growth factor binding protein-5 (IGFBP-5) suppresses the tumourigenesis of head and neck squamous cell carcinoma

P Hung
  • J. Pathol
  • 2008