Senescence marker protein 30 functions as gluconolactonase in L-ascorbic acid biosynthesis, and its knockout mice are prone to scurvy.

@article{Kondo2006SenescenceMP,
  title={Senescence marker protein 30 functions as gluconolactonase in L-ascorbic acid biosynthesis, and its knockout mice are prone to scurvy.},
  author={Yoshitaka Kondo and Yoko Inai and Y Sato and Setsuko Handa and Sachiho Kubo and Kentaro Shimokado and Sataro Goto and Morimitsu Nishikimi and Naoki Maruyama and Akihito Ishigami},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 15},
  pages={5723-8}
}
We originally identified senescence marker protein 30 (SMP30) as a distinctive protein whose expression decreases in an androgen-independent manner with aging. Here, we report its sequence homology found in two kinds of bacterial gluconolactonases (GNLs) by using the blast search. Then, through a biochemical study, we identify SMP30 as the lactone-hydrolyzing enzyme GNL of animal species. SMP30 purified from the rat liver had lactonase activity toward various aldonolactones, such as d- and l… CONTINUE READING
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Vitamin C and the Scurvy-Prone ODS Rat

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