Senescence in human intervertebral discs

  title={Senescence in human intervertebral discs},
  author={Sally Roberts and Elizabeth H Evans and Dimitris Kletsas and David C. Jaffray and Stephen M. Eisenstein},
  journal={European Spine Journal},
Intervertebral discs demonstrate degenerative changes relatively early in life. Disc degeneration, in turn, is associated with back pain and disc herniation, both of which cause considerable clinical problems in the western world. Cell senescence has been linked to degenerative diseases of other connective tissues such as osteoarthritis. Thus we investigated the degree of cell senescence in different regions of discs from patients with different disc disorders. Discs were obtained from 25… CONTINUE READING