Senescence in a Bacterium with Asymmetric Division

  title={Senescence in a Bacterium with Asymmetric Division},
  author={Martin Ackermann and Stephen C. Stearns and Urs Jenal},
  pages={1920 - 1920}
Senescence (or aging) is a deterioration of function with age manifested as a drop in survival and reproduction ( [1][1] ). A fundamental question about senescence has not been settled: Which organisms should be senescent, and which should be potentially immortal? We present evidence for senescence 
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Senescence can explain microbial persistence.
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Facts are considered showing that novel forms of aging and mechanisms counteracting them, antiaging systems, have appeared simultaneously with development of the evolutionary form.
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Bacterial aging: from mechanistic basis to evolutionary perspective
In this paper, the current view on the mechanistic background and evolutionary significance of bacterial kind of aging is presented, with particular emphasis on the role of asymmetric cell division, the characteristics of stationary growth phase, and therole of oxidative protein damage.


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Evidence for the importance of both selection against late-acting mutations and selection against deleterious mutations is emerging, and unravelling their relative importance presents experimentalists with a major challenge.
Asymmetric Inheritance of Oxidatively Damaged Proteins During Cytokinesis
Findings suggest that a genetically determined, Sir2p-dependent asymmetric inheritance of oxidatively damaged proteins may contribute to free-radical defense and the fitness of newborn cells.
Generating and Exploiting Polarity in Bacteria
Some of the schemes bacteria use to orchestrate dynamic changes at their poles and how these polar events execute cellular functions are explored.
Evolutionary biology of aging
The evolutionary theory of aging Observation of aging Experimental tests of the evolutionary theory of aging Genetic mechanisms form the evolution of aging Comparative biology of aging An
Life Span of Individual Yeast Cells
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Materials and methods are available as supporting material on Science Online
  • Materials and methods are available as supporting material on Science Online