Senescence in Health and Disease

@article{He2017SenescenceIH,
  title={Senescence in Health and Disease},
  author={Shenghui He and Norman E Sharpless},
  journal={Cell},
  year={2017},
  volume={169},
  pages={1000-1011}
}
Many cellular stresses activate senescence, a persistent hyporeplicative state characterized in part by expression of the p16INK4a cell-cycle inhibitor. Senescent cell production occurs throughout life and plays beneficial roles in a variety of physiological and pathological processes including embryogenesis, wound healing, host immunity, and tumor suppression. Meanwhile, the steady accumulation of senescent cells with age also has adverse consequences. These non-proliferating cells occupy key… CONTINUE READING
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