Senescence evasion by MCF-7 human breast tumor-initiating cells

@inproceedings{KarimiBusheri2009SenescenceEB,
  title={Senescence evasion by MCF-7 human breast tumor-initiating cells},
  author={Feridoun Karimi-Busheri and Aghdass Rasouli-Nia and John R. Mackey and Michael Weinfeld},
  booktitle={Breast Cancer Research},
  year={2009}
}
A subpopulation of cancer cells, tumor-initiating cells, is believed to be the driving force behind tumorigenesis and resistance to radiation and chemotherapy. The persistence of tumor-initiating cells may depend on altered regulation of DNA damage and checkpoint proteins, as well as a reduced propensity to undergo apoptosis or senescence. To test this hypothesis, we isolated CD24-/low/CD44+ tumor-initiating cells (as mammospheres) from MCF-7 breast cancer cells grown in adherent monolayer… CONTINUE READING

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