Senescence and tumor suppression

@inproceedings{Hinds2017SenescenceAT,
  title={Senescence and tumor suppression},
  author={Philip Hinds and Jodie R. Pietruska},
  booktitle={F1000Research},
  year={2017}
}
Cellular senescence has emerged as a potent tumor suppression mechanism that restrains proliferation of cells at risk for malignant transformation. Although senescent cells have permanently exited the cell cycle, their presence can have detrimental effects on the surrounding tissue, largely due to the development of the senescence-associated secretory phenotype (SASP). Here, we review the tumor-suppressive and tumor-promoting consequences of the senescence response, focusing on the SASP as a… CONTINUE READING

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