Senescence and p130/Rbl2: a new beginning to the end

  title={Senescence and p130/Rbl2: a new beginning to the end},
  author={Francesco P Fiorentino and Catherine E. Symonds and Marcella Macaluso and Antonio Giordano},
  journal={Cell Research},
Senescence is the process of cellular aging dependent on the normal physiological functions of non-immortalized cells. With increasing data being uncovered in this field, the complex molecular web regulating senescence is gradually being unraveled. Recent studies have suggested two main phases of senescence, the triggering of senescence and the maintenance of senescence. Each has been supported by data implying precise roles for DNA methyltransferases, reactive oxygen species and other factors… CONTINUE READING

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