Senescence and cytokines modulate the NK cell expression.

  title={Senescence and cytokines modulate the NK cell expression.},
  author={Rajabather Krishnaraj},
  journal={Mechanisms of ageing and development},
  volume={96 1-3},
We have been investigating senescence-related changes in human peripheral blood natural killer (NK2) cells. Data accumulated so far consistently and clearly show that both basal and cytokine (IL-2 and interferon alpha and gamma) induced antitumor MHC-unrestricted cytotoxic activity of NK cells are well-preserved in the healthy elderly. To investigate if the non-cytotoxic functions of NK cells are also spared from the influence of senescence, recombinant IL-2-inducible secretion of IFN-gamma… CONTINUE READING


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