Senescence Mediated by p16INK4a Impedes Reprogramming of Human Corneal Endothelial Cells into Neural Crest Progenitors

@inproceedings{Lu2016SenescenceMB,
  title={Senescence Mediated by p16INK4a Impedes Reprogramming of Human Corneal Endothelial Cells into Neural Crest Progenitors},
  author={W. L. Lu and Scheffer C. G. Tseng and Shuangling Chen and Sean Tighe and Yuan Zhang and Xin Liu and Szu-yu Chen and Chen-Wei Su and Yingting Zhu},
  booktitle={Scientific reports},
  year={2016}
}
Human corneal endothelial cells (HCECs) have limited proliferative capacity due to "contact-inhibition" at G1 phase. Such contact-inhibition can be delayed from Day 21 to Day 42 by switching EGF-containing SHEM to LIF/bFGF-containing MESCM through transient activation of LIF-JAK1-STAT3 signaling that delays eventual nuclear translocation of p16INK4a. Using… CONTINUE READING