Senescence‐associated β‐galactosidase is lysosomal β‐galactosidase

@article{Lee2006SenescenceassociatedI,
  title={Senescence‐associated $\beta$‐galactosidase is lysosomal $\beta$‐galactosidase},
  author={Bo Yun Lee and Jung An Han and Jun-Sub Im and Amelia Morrone and Kimberly L. Johung and Edward C. Goodwin and Wim J. Kleijer and Daniel DiMaio and Eun Seong Hwang},
  journal={Aging Cell},
  year={2006},
  volume={5}
}
Replicative senescence limits the proliferation of somatic cells passaged in culture and may reflect cellular aging in vivo. The most widely used biomarker for senescent and aging cells is senescence‐associated β‐galactosidase (SA‐β‐gal), which is defined as β‐galactosidase activity detectable at pH 6.0 in senescent cells, but the origin of SA‐β‐gal and its cellular roles in senescence are not known. We demonstrate here that SA‐β‐gal activity is expressed from GLB1, the gene encoding lysosomal… Expand
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