Senegal haplotype is associated with higher HbF than benin and cameroon haplotypes in African children with sickle cell anemia

@article{Green1993SenegalHI,
  title={Senegal haplotype is associated with higher HbF than benin and cameroon haplotypes in African children with sickle cell anemia},
  author={Nancy S. Green and Mary E. Fabry and L Kaptue-Noche and Ronald L. Nagel},
  journal={American Journal of Hematology},
  year={1993},
  volume={44}
}

Emerging Science of Hydroxyurea Therapy for Pediatric Sickle Cell Disease

Hydroxyurea (HU) is the sole approved pharmacological therapy for sickle cell disease (SCD). Higher levels of fetal hemoglobin (HbF) diminish deoxygenated sickle globin polymerization in vitro and

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Hematological and molecular analyses of the HbS allele among the Sudanese population

As a result of sickle cell anemia, this investigation found changes in hematological parameters in the Sudanese population, and a new haplotype of the S gene was discovered.

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HbS is a homozygous type of Sickle Cell Anaemia (HbSS). This is the product of a single point substitution of β-globin chain valine for glutamine 6. This limits the solubility of the red cells, which

Association between BCL11A, HSB1L-MYB, and XmnI γG-158 (C/T) gene polymorphism and hemoglobin F level in Egyptian sickle cell disease patients

Investigating HbF-enhancer haplotypes at BCL11A, HSB1L, and Xmn1 genetic polymorphisms to obtain a first overview of the genetic situation of SCD patients in Egypt and its impact on the severity of the disease found them to have no positive impact on baselineHbF levels solely but had if coexisted.

Evaluation of correlation between clinical profile and amount of abnormal hemoglobin in sickle cell hemoglobinopathy

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Immunogenetics in sickle cell disease

The role of inflammatory genes encoding Toll-like receptors (TLR) in the occurrence of bacterial infections in patients with SCD was assessed, because infection is a leading cause of mortality in SCD, and TLR recognize a wide range of bacteria.

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