Seneca Valley Virus Suppresses Host Type I Interferon Production by Targeting Adaptor Proteins MAVS, TRIF, and TANK for Cleavage.

@article{Qian2017SenecaVV,
  title={Seneca Valley Virus Suppresses Host Type I Interferon Production by Targeting Adaptor Proteins MAVS, TRIF, and TANK for Cleavage.},
  author={Suhong Qian and Wenchun Fan and Tingting Liu and Mengge Wu and Huawei Zhang and Xiaofang Cui and Yun Zhou and Junjie Hu and Shaozhong Wei and Huan Chen and Xiangmin Li and Ping Qian},
  journal={Journal of virology},
  year={2017},
  volume={91 16}
}
Seneca Valley virus (SVV) is an oncolytic RNA virus belonging to the Picornaviridae family. Its nucleotide sequence is highly similar to those of members of the Cardiovirus genus. SVV is also a neuroendocrine cancer-selective oncolytic picornavirus that can be used for anticancer therapy. However, the interaction between SVV and its host is yet to be fully characterized. In this study, SVV inhibited antiviral type I interferon (IFN) responses by targeting different host adaptors, including… CONTINUE READING