Sendai virus binds to a dispersed population of NBD-GD1a.

  title={Sendai virus binds to a dispersed population of NBD-GD1a.},
  author={Jonathan V. Rocheleau and Nils O. Petersen},
  journal={Bioscience reports},
  volume={20 3},
Receptor aggregation is believed to be an important step in the attachment of membrane enveloped virus' to target cell membranes. A likely receptor for Sendai virus is the ganglioside GD1a. In this work we have studied the membrane diffusion of the fluorescent ganglioside NBD-GD1a on the surface of CV-1 cells with standard photobleaching techniques. Using confocal laser scanning microscopy (CLSM) and Image Correlation Spectroscopy (ICS) NBD-GD1a is shown to exist in at least two populations… CONTINUE READING