Sendai virus C proteins are categorically nonessential gene products but silencing their expression severely impairs viral replication and pathogenesis.

@article{Kurotani1998SendaiVC,
  title={Sendai virus C proteins are categorically nonessential gene products but silencing their expression severely impairs viral replication and pathogenesis.},
  author={A Kurotani and Katsuhiro Kiyotani and Atsushi Kato and Tatsuo Shioda and Yuko T. Sakai and Kiyohisa Mizumoto and Tetsuya Yoshida and Yoshiyuki Nagai},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  year={1998},
  volume={3 2},
  pages={111-24}
}
BACKGROUND The P/C mRNA of Sendai virus (SeV), a prototypic member of the family Paramyxoviridae in the Mononegavirales superfamily comprising a large number of nonsegmented negative strand RNA viruses, encodes a nested set of accessory proteins, C', C, Y1 and Y2, referred to collectively as C proteins, initiating, respectively, at ACG/81 and AUGs/114, 183, 201 in the +1 frame relative to the ORF of phospho (P) protein, the smaller subunit of RNA polymerase. Among them, C is the major species… CONTINUE READING

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