Sendai virus C protein impairs both phosphorylation and dephosphorylation processes of Stat1.

@article{Komatsu2002SendaiVC,
  title={Sendai virus C protein impairs both phosphorylation and dephosphorylation processes of Stat1.},
  author={Takayuki Komatsu and Kenji Takeuchi and Junko Yokoo and Bin Gotoh},
  journal={FEBS letters},
  year={2002},
  volume={511 1-3},
  pages={139-44}
}
Sendai virus expresses C protein that blocks interferon (IFN) signaling. We previously reported suppression of IFN-stimulated tyrosine phosphorylation of signal transducers and activators of transcription (Stats) in infected cells. However this conclusion has remained controversial. To settle it, we re-examined the effect of C protein expression on phosphorylation of Stat1 in detail. IFN-stimulated tyrosine phosphorylation of Stat1 was doubtlessly suppressed early in infection, but the… CONTINUE READING

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