Send in the clamps: control of DNA translesion synthesis in eukaryotes.

@article{Jansen2007SendIT,
  title={Send in the clamps: control of DNA translesion synthesis in eukaryotes.},
  author={Jacob G. Jansen and Maria I. Fousteri and Niels de Wind},
  journal={Molecular cell},
  year={2007},
  volume={28 4},
  pages={522-9}
}
The replication of damaged DNA templates by translesion synthesis (TLS) is associated with mutagenesis and carcinogenesis. This perspective discusses the different levels at which TLS may be controlled and proposes a model for TLS of severely helix-distorting DNA lesions that includes a decisive role for the Rad9-Hus1-Rad1 DNA-damage-signaling clamp. The… CONTINUE READING