Semliki forest virus expressing interleukin-12 induces antiviral and antitumoral responses in woodchucks with chronic viral hepatitis and hepatocellular carcinoma.

@article{RodriguezMadoz2009SemlikiFV,
  title={Semliki forest virus expressing interleukin-12 induces antiviral and antitumoral responses in woodchucks with chronic viral hepatitis and hepatocellular carcinoma.},
  author={Juan Roberto Rodriguez-Madoz and Katherine H Liu and Jos{\'e} Ignacio Quetglas and Marta Ruiz-Guillen and Itziar Otano and Julien S Crettaz and Scott D Butler and Christine A. Bellezza and Nathan L. Dykes and Bud Christopher Tennant and Jes{\'u}s Prieto and Gloria Gonzalez-Aseguinolaza and Cristian Smerdou and Stephan Menne},
  journal={Journal of virology},
  year={2009},
  volume={83 23},
  pages={12266-78}
}
A vector based on Semliki Forest virus (SFV) expressing high levels of interleukin-12 (SFV-enhIL-12) has previously demonstrated potent antitumoral efficacy in small rodents with hepatocellular carcinoma (HCC) induced by transplantation of tumor cells. In the present study, the infectivity and antitumoral/antiviral effects of SFV vectors were evaluated in the clinically more relevant woodchuck model, in which primary HCC is induced by chronic infection with woodchuck hepatitis virus (WHV… CONTINUE READING
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