Semisynthetic production of unnatural L-α-amino acids by metabolic engineering of the cysteine-biosynthetic pathway

@article{Maier2003SemisyntheticPO,
  title={Semisynthetic production of unnatural L-$\alpha$-amino acids by metabolic engineering of the cysteine-biosynthetic pathway},
  author={Thomas Maier},
  journal={Nature Biotechnology},
  year={2003},
  volume={21},
  pages={422-427}
}
  • T. Maier
  • Published 2003
  • Biology, Medicine
  • Nature Biotechnology
There is an increasing demand for peptide-mimicking molecules to modulate the interactions between proteins of pharmaceutical and agrochemical interest and their target polypeptides. Unnatural L-α-amino acids differing from the 20 naturally proteinogenic amino acids only in their side chain are ideal for this purpose, but their chemical synthesis is complex. Here we describe a fermentation-based approach for biosynthesis of unnatural amino acids after re-engineering the cysteine-biosynthetic… Expand
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