Semisynthetic preparation of leucomycin derivatives: Introduction of aromatic side chains by reductive amination

Abstract

A small library of leucomycin A7 derivatives was prepared by NaCNBH3/ZnCl2-mediated reductive amination of the C18 aldehyde moiety with a variety of lipophilic benzylamines and tested for antibiotic activity. 
DOI: 10.1007/s11030-005-1304-z

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