Semisynthetic beta-lactam antibiotics. IV. Synthesis and antibacterial activity of 7 beta-[2-(hetero aromatic methoxyimino)-2-(2-aminothiazol-4-yl)acetamido]cephalosporins.

@article{Arimoto1988SemisyntheticBA,
  title={Semisynthetic beta-lactam antibiotics. IV. Synthesis and antibacterial activity of 7 beta-[2-(hetero aromatic methoxyimino)-2-(2-aminothiazol-4-yl)acetamido]cephalosporins.},
  author={Misao Arimoto and Shigeharu Yokohama and Manabu Sudou and Yusuke Ichikawa and Toshiya Hayano and Hiroyuki Tagawa and Makoto Furukawa},
  journal={The Journal of antibiotics},
  year={1988},
  volume={41 12},
  pages={1795-811}
}
A series of 7 beta-[2-(hetero aromatic methoxyimino)-2-(2-aminothiazol-4-yl)acetamido]- cephalosporins have been synthesized and bacteriologically evaluated. Several substances in this series showed exceptional in vitro activity, especially those with a five-membered hetero aromatic substituent moiety at the 7-position and a quaternary ammonium group as the… CONTINUE READING