Semisynthetic aminoglycoside antibiotics. IV. 3',4'-Dideoxyparomomycin and analogues.

  title={Semisynthetic aminoglycoside antibiotics. IV. 3',4'-Dideoxyparomomycin and analogues.},
  author={Carlo Battistini and Giovanni Franceschi and Franco Zarini and Giuseppe Cassinelli and Federico Arcamone and Aurora Sanfilippo},
  journal={The Journal of antibiotics},
  volume={35 1},
Synthesis of a Pseudotrisaccharide Suitable for Synthesis of Ring I Modified 4,5-2-Deoxystreptamine Type Aminoglycoside Antibiotics.
A cleavage of ring I from paromomycin that proceeds in the presence of azides and affords a glycosyl acceptor for the installation of a modified ring I is described.
Fifty years of chemical research at Farmitalia.
This review contains a brief description of the chemistry developed in Farmitalia and, after 1978, Farmitalian-Carlo Erba Research Laboratories, during the second half of the last century, in the field of medicinal and natural product chemistry.
Paromomycin and Geneticin Inhibit IntracellularCryptosporidium parvum without Trafficking through the Host Cell Cytoplasm: Implications for Drug Delivery
The apical membranes overlying the parasite and parasitophorous vacuole may be the unsuspected major route of entry for paromomycin and may be of importance in the design and discovery of novel drug therapies for the otherwise untreatable C. parvum.


An improved synthesis of 3',4'-dideoxykanamycin B.
A new synthetic route has been exploited for the large scale production of 3′,4′-dideoxykanamycin B starting with kanamycin B. The key stage in the synthesis involves the formation in excellent yield
Purification and characterization of an aminoglycoside inactivating enzyme from Staphylococcus epidermidis FK109 that nucleotidylates the 4'- and 4''-hydroxyl groups of the aminoglycoside antibiotics.
The ability of the enzyme ANT (4', 4'') to modify the two hydroxyl groups of aminoglycoside molecules, enables it to have a spectrum of substrates that surpasses, in range, the substrate spectrum of all the aminglycoside-modifying enzymes which have been characterized hitherto.
Preparation of unsaturated carbohydrates. A facile synthesis of methyl 4,6-O-Benzylidene-D-hex-2-enopyranosides
A simple method was explored for the preparation of methyl 4,6-O-benzylidene-hex-2-enopyranosides. Methyl 2,3-anhydro-4,6-O-benzylidene-D-hexopyranosides were converted to diaxial iodohydrins using