Semisynthetic aminoglycoside antibiotics. IV. 3',4'-Dideoxyparomomycin and analogues.

@article{Battistini1982SemisyntheticAA,
  title={Semisynthetic aminoglycoside antibiotics. IV. 3',4'-Dideoxyparomomycin and analogues.},
  author={Carlo Battistini and Giovanni Franceschi and Franco Zarini and Giuseppe Cassinelli and Federico Arcamone and Aurora Sanfilippo},
  journal={The Journal of antibiotics},
  year={1982},
  volume={35 1},
  pages={
          98-101
        }
}
Synthesis of a Pseudotrisaccharide Suitable for Synthesis of Ring I Modified 4,5-2-Deoxystreptamine Type Aminoglycoside Antibiotics.
TLDR
A cleavage of ring I from paromomycin that proceeds in the presence of azides and affords a glycosyl acceptor for the installation of a modified ring I is described.
Fifty years of chemical research at Farmitalia.
TLDR
This review contains a brief description of the chemistry developed in Farmitalia and, after 1978, Farmitalian-Carlo Erba Research Laboratories, during the second half of the last century, in the field of medicinal and natural product chemistry.
Paromomycin and Geneticin Inhibit IntracellularCryptosporidium parvum without Trafficking through the Host Cell Cytoplasm: Implications for Drug Delivery
TLDR
The apical membranes overlying the parasite and parasitophorous vacuole may be the unsuspected major route of entry for paromomycin and may be of importance in the design and discovery of novel drug therapies for the otherwise untreatable C. parvum.

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