Semisynthetic aminoglycoside antibiotics. IV. 3',4'-Dideoxyparomomycin and analogues.
@article{Battistini1982SemisyntheticAA, title={Semisynthetic aminoglycoside antibiotics. IV. 3',4'-Dideoxyparomomycin and analogues.}, author={Carlo Battistini and Giovanni Franceschi and Franco Zarini and Giuseppe Cassinelli and Federico Arcamone and Aurora Sanfilippo}, journal={The Journal of antibiotics}, year={1982}, volume={35 1}, pages={ 98-101 } }
6 Citations
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This review contains a brief description of the chemistry developed in Farmitalia and, after 1978, Farmitalian-Carlo Erba Research Laboratories, during the second half of the last century, in the field of medicinal and natural product chemistry.
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The ability of the enzyme ANT (4', 4'') to modify the two hydroxyl groups of aminoglycoside molecules, enables it to have a spectrum of substrates that surpasses, in range, the substrate spectrum of all the aminglycoside-modifying enzymes which have been characterized hitherto.
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