Semisynthetic aminoglycoside antibiotics: Development and enzymatic modifications

@article{Kondo1999SemisyntheticAA,
  title={Semisynthetic aminoglycoside antibiotics: Development and enzymatic modifications},
  author={S. Kondo and K. Hotta},
  journal={Journal of Infection and Chemotherapy},
  year={1999},
  volume={5},
  pages={1-9}
}
  • S. Kondo, K. Hotta
  • Published 1999
  • Biology, Medicine
  • Journal of Infection and Chemotherapy
  • Abstract The critical resistance mechanisms of aminoglycoside antibiotics in bacteria of clinical importance are the enzymatic N-acetylation, O-phosphorylation, and O-nucleotidylation that generally result in the inactivation of aminoglycosides. To overcome such resistance mechanisms, dibekacin (3′,4′-dideoxykanamycin B) was developed as the first rationally designed semisynthetic aminoglycoside, based on the enzymatic 3′-O-phosphorylation of kanamycin. Subsequently, amikacin, netilmicin, and… CONTINUE READING
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    References

    SHOWING 1-10 OF 50 REFERENCES
    Enzymatic 2'-N-acetylation of arbekacin and antibiotic activity of its product.
    • 34
    BB-K 8, a new semisynthetic aminoglycoside antibiotic.
    • 286
    Biochemical mechanism of resistance to aminoglycosidic antibiotics.
    • H. Umezawa
    • Chemistry, Medicine
    • Advances in carbohydrate chemistry and biochemistry
    • 1974
    • 94
    Antibacterial activity and nephrotoxicity of two novel 2″-amino derivatives of arbekacin
    • 3
    Tobramycin adenylyltransferase: a new aminoglycoside-inactivating enzyme from Staphylococcus epidermidis.
    • 27
    • PDF
    Structures and syntheses of aminoglycoside antibiotics.
    • S. Umezawa
    • Chemistry, Medicine
    • Advances in carbohydrate chemistry and biochemistry
    • 1974
    • 121