Semisynthetic aminoglycoside antibiotics: Development and enzymatic modifications

  title={Semisynthetic aminoglycoside antibiotics: Development and enzymatic modifications},
  author={S. Kondo and K. Hotta},
  journal={Journal of Infection and Chemotherapy},
  • S. Kondo, K. Hotta
  • Published 1999
  • Biology, Medicine
  • Journal of Infection and Chemotherapy
  • Abstract The critical resistance mechanisms of aminoglycoside antibiotics in bacteria of clinical importance are the enzymatic N-acetylation, O-phosphorylation, and O-nucleotidylation that generally result in the inactivation of aminoglycosides. To overcome such resistance mechanisms, dibekacin (3′,4′-dideoxykanamycin B) was developed as the first rationally designed semisynthetic aminoglycoside, based on the enzymatic 3′-O-phosphorylation of kanamycin. Subsequently, amikacin, netilmicin, and… CONTINUE READING
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