Semisynthesis and cytotoxic activities of andrographolide analogues.

  title={Semisynthesis and cytotoxic activities of andrographolide analogues.},
  author={Srinivasa Rao Jada and Ahmad Sazali Hamzah and Nordin Haji Lajis and Mohammad Said Saad and Malcolm F. G. Stevens and Johnson Stanslas},
  journal={Journal of enzyme inhibition and medicinal chemistry},
  volume={21 2},
Andrographolide 1, a diterpenoid lactone of the plant Andrographis paniculata, known to possess antitumour activity in in vitro and in vivo breast cancer models was subjected to semisynthesis leading to the preparation of a number of novel compounds. These compounds exhibited in vitro antitumour activity with moderate to excellent growth inhibition against MCF-7 (breast) and HCT-116 (colon) cancer cells. Compounds 3,19-(2-chlorobenzylidene)andrographolide(5), 3,19-(3-chlorobenzylidene… CONTINUE READING