Semisynthesis, Characterization and Evaluation of New Adenosine Derivatives as Antiproliferative Agents.


We describe the semisynthesis and biological effects of adenosine derivatives, which were anticipated to function as agonists for the A₃ receptor. Molecular docking was used to select candidate compounds. Fifteen nucleoside derivatives were obtained through nucleophilic substitutions of the N⁶-position of the nucleoside precursor 6-chloropurine riboside by… (More)
DOI: 10.3390/molecules23051111

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