Semiquantitative analysis by scanning electron microscopy of cochlear hair cell damage by ototoxic drugs.

@article{Saito1995SemiquantitativeAB,
  title={Semiquantitative analysis by scanning electron microscopy of cochlear hair cell damage by ototoxic drugs.},
  author={Takehisa Saito and Yasuhiro Manabe and Nobuaki Honda and Tatsuo Yamada and Takehito Yamamoto and Hitoshi Saito},
  journal={Scanning microscopy},
  year={1995},
  volume={9 1},
  pages={271-80; discussion 280-1}
}
The ototoxicity of cisplatin and carboplatin in the organ of Corti of the guinea pig was evaluated semiquantitatively. Damage of the stereocilia of outer hair cells (OHCs) observed by scanning electron microscopy (SEM) was classified into normal, grade 1 (10-50% loss of stereocilia), grade 2 (less than 50% remaining stereocilia), or grade 3 (missing stereocilia). The OHCs observed by light microscopy (LM) were classified as remaining or missing cells. Fifty OHCs of each row in the middle part… CONTINUE READING

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Attenuation of cisplatin ototoxicity by otoprotective effects of nanoencapsulated curcumin and dexamethasone in a guinea pig model.

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology • 2014
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