Semiparametric mixed-effects analysis of PK/PD models using differential equations

@article{Wang2008SemiparametricMA,
  title={Semiparametric mixed-effects analysis of PK/PD models using differential equations},
  author={Yi Wang and Kent M. Eskridge and Shunpu Zhang},
  journal={Journal of Pharmacokinetics and Pharmacodynamics},
  year={2008},
  volume={35},
  pages={443-463}
}
Motivated by the use of semiparametric nonlinear mixed-effects modeling on longitudinal data, we develop a new semiparametric modeling approach to address potential structural model misspecification for population pharmacokinetic/pharmacodynamic (PK/PD) analysis. Specifically, we use a set of ordinary differential equations (ODEs) with form dx/dt = A(t)x + B(t) where B(t) is a nonparametric function that is estimated using penalized splines. The inclusion of a nonparametric function in the ODEs… CONTINUE READING
5 Citations
25 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 25 references

Semiparametric mixed-effects analysis on PK/PD models using differential equations, Ph.D. Dissertation

  • Y Wang
  • University of Nebraska,
  • 2008
Highly Influential
6 Excerpts

Semiparametric nonlinear mixed models and their applications

  • C Ke, Y Wang
  • J Am Stat Assoc 96:1272–1298
  • 2001
Highly Influential
8 Excerpts

Similar Papers

Loading similar papers…