Semiparametric mixed-effects analysis of PK/PD models using differential equations

  title={Semiparametric mixed-effects analysis of PK/PD models using differential equations},
  author={Yi Wang and Kent M. Eskridge and Shunpu Zhang},
  journal={Journal of Pharmacokinetics and Pharmacodynamics},
Motivated by the use of semiparametric nonlinear mixed-effects modeling on longitudinal data, we develop a new semiparametric modeling approach to address potential structural model misspecification for population pharmacokinetic/pharmacodynamic (PK/PD) analysis. Specifically, we use a set of ordinary differential equations (ODEs) with form dx/dt = A(t)x + B(t) where B(t) is a nonparametric function that is estimated using penalized splines. The inclusion of a nonparametric function in the ODEs… CONTINUE READING
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