Semiparametric integrative interaction analysis for non-small-cell lung cancer

  title={Semiparametric integrative interaction analysis for non-small-cell lung cancer},
  author={Yang Li and Fan Wang and Rong Li and Yifan Sun},
  journal={Statistical Methods in Medical Research},
  pages={2865 - 2880}
In genomic analysis, it is significant though challenging to identify markers associated with cancer outcomes or phenotypes. Based on the biological mechanisms of cancers and the characteristics of datasets, we propose a novel integrative interaction approach under a semiparametric model, in which genetic and environmental factors are included as the parametric and nonparametric components, respectively. The goal of this approach is to identify the genetic factors and gene–gene interactions… 

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