Semiparametric estimation of random effects using the Cox model based on the EM algorithm.

@article{Klein1992SemiparametricEO,
  title={Semiparametric estimation of random effects using the Cox model based on the EM algorithm.},
  author={John P. Klein},
  journal={Biometrics},
  year={1992},
  volume={48 3},
  pages={795-806}
}
Consider a survival experiment where individuals within a certain subset of the population share a common, unobservable, random frailty. Such a frailty could be an unobservable genetic or early environmental effect if individuals were in sibling groups or an environmental effect if individuals were grouped by households. Suppose that if the frailty, omega, is known, the Cox proportional hazards model for the observable covariates is valid with the consequence of the random effect being a… CONTINUE READING
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