Seminiferous cord formation and germ-cell programming: epigenetic transgenerational actions of endocrine disruptors.

@article{Skinner2005SeminiferousCF,
  title={Seminiferous cord formation and germ-cell programming: epigenetic transgenerational actions of endocrine disruptors.},
  author={Michael K. Skinner and Matthew D. Anway},
  journal={Annals of the New York Academy of Sciences},
  year={2005},
  volume={1061},
  pages={
          18-32
        }
}
The molecular and cellular control of embryonic testis development was investigated through an analysis of the embryonic testis transcriptome to identify potential regulatory factors for male sex determination and testis morphogenesis. One critical factor identified is neurotropin 3 (NT3). At the onset of male sex determination, Sertoli cells initiate differentiation and express NT3 to act as a chemotactic factor for mesonephros cells to migrate and associate with Sertoli-germ cell aggregates… CONTINUE READING
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