Semiautomated microfluorometric instrument and reagent system for monitoring disease-related immunosuppression.

@article{Ranney1982SemiautomatedMI,
  title={Semiautomated microfluorometric instrument and reagent system for monitoring disease-related immunosuppression.},
  author={D. Ranney and A. J. Quattrone},
  journal={Clinical chemistry},
  year={1982},
  volume={28 9},
  pages={
          1887-93
        }
}
  • D. Ranney, A. J. Quattrone
  • Published 1982
  • Chemistry, Medicine
  • Clinical chemistry
  • Several common metabolites and drugs in the serum in of patients with inflammatory, infectious, autoimmune, immunodeficient, neoplastic, and toxicant-induced diseases can produce artifactual suppression of the [methyl-3H]-thymidine assay, which is widely used to evaluate lymphocyte responsiveness. We have developed a sensitive, semiautomated, fluorescence-enhancement assay in which true immunosuppressors are measured in the presence of absence of such interfering substances. Peripheral blood… CONTINUE READING

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