Semi-synthesis and anti-proliferative activity evaluation of novel analogues of Honokiol.

Abstract

A series of honokiol analogues were synthesized by modifying the 5- and/or 3'-position(s) of honokiol to assess their anti-tumor effects. Some compounds exerted more potent anti-proliferative activities than those of honokiol on K562 leukemia cells, A549 alveolar basal epithelial cells, SPC-A1 adenocarcinoma cells and A2780 human ovarian carcinoma cells in… (More)
DOI: 10.1016/j.bmcl.2009.06.071

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