Semi-purification of the immunoglobulin E-sweat antigen acting on mast cells and basophils in atopic dermatitis.

@article{Tanaka2006SemipurificationOT,
  title={Semi-purification of the immunoglobulin E-sweat antigen acting on mast cells and basophils in atopic dermatitis.},
  author={Arata Tanaka and Takao Tanaka and Hiroyuki Suzuki and Kaori Ishii and Yoshikazu Kameyoshi and Kazumasa Iwamoto},
  journal={Experimental dermatology},
  year={2006},
  volume={15 4},
  pages={283-90}
}
BACKGROUND Sweating aggravates the symptoms of atopic dermatitis (AD). We have recently reported positive skin reactions and histamine release from basophils in response to autologous sweat in patients with AD. OBJECTIVE To characterize the biochemical and immunological properties of the substance in sweat that evokes histamine release and to study the usability of the basophil-histamine release test with the sweat antigen for AD. METHODS Sweat collected from healthy volunteers was purified… CONTINUE READING

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