Semi-mechanistic population pharmacokinetic drug-drug interaction modelling of a long half-life substrate and itraconazole.

@article{Lehr2010SemimechanisticPP,
  title={Semi-mechanistic population pharmacokinetic drug-drug interaction modelling of a long half-life substrate and itraconazole.},
  author={Thorsten Lehr and Alexander Staab and Dirk Trommeshauser and Hans Guenter Schaefer and Charlotte Kloft},
  journal={Clinical pharmacokinetics},
  year={2010},
  volume={49 1},
  pages={53-66}
}
BACKGROUND For compounds with a long elimination half-life, the evaluation of a drug-drug interaction (DDI) study can be challenging. The standard analytical approach of a non-compartmental analysis (NCA) might not be able to detect the full interaction potential and may lead to a significant underestimation of the interaction. The most appropriate method for data analysis might be a semi-mechanistic population pharmacokinetic modelling approach. OBJECTIVES To accomplish a semi-mechanistic… CONTINUE READING