Semi-allogeneic dendritic cells can induce antigen-specific T-cell activation, which is not enhanced by concurrent alloreactivity

@article{Wells2007SemiallogeneicDC,
  title={Semi-allogeneic dendritic cells can induce antigen-specific T-cell activation, which is not enhanced by concurrent alloreactivity},
  author={James W Wells and Christopher J Cowled and David Darling and Barbara-ann Guinn and Farzin Farzaneh and Alistair Noble and Joanna Galea-Lauri},
  journal={Cancer Immunology, Immunotherapy},
  year={2007},
  volume={56},
  pages={1861-1873}
}
Alloreactive T-cell responses are known to result in the production of large amounts of proinflammatory cytokines capable of activating and maturing dendritic cells (DC). However, it is unclear whether these allogeneic responses could also act as an adjuvant for concurrent antigen-specific responses. To examine effects of simultaneous alloreactive and… CONTINUE READING