Semi-LASER 1 H MR spectroscopy at 7 Tesla in human brain: Metabolite quantification incorporating subject-specific macromolecule removal.

@article{Penner2015SemiLASER1H,
  title={Semi-LASER 1 H MR spectroscopy at 7 Tesla in human brain: Metabolite quantification incorporating subject-specific macromolecule removal.},
  author={Jacob Penner and Robert Bartha},
  journal={Magnetic resonance in medicine},
  year={2015},
  volume={74 1},
  pages={
          4-12
        }
}
PURPOSE To develop an in vivo 1 H short-echo-time semi-LASER spectroscopy protocol at 7 Tesla (T) incorporating subject-specific macromolecule removal. METHODS T1 constants of the major metabolites were measured with little macromolecule contribution in seven healthy volunteers and used to optimize double inversion metabolite nulling. Spectra were acquired from parietal-occipital cortex of five healthy volunteers. Metabolite-nulled macromolecule spectra were subtracted from the metabolite… CONTINUE READING

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