Semenogelin I: a coagulum forming, multifunctional seminal vesicle protein

  title={Semenogelin I: a coagulum forming, multifunctional seminal vesicle protein},
  author={Martin Robert and Claude Gagnon},
  journal={Cellular and Molecular Life Sciences CMLS},
Human seminal plasma spontaneously coagulates after ejaculation. The major component of this coagulum is semenogelin I, a 52-kDa protein expressed exclusively in the seminal vesicles. Recently, a sperm motility inhibitor has been found to be identical to semenogelin I, suggesting that it may also be a physiological sperm motility inhibitor. The protein is rapidly cleaved after ejaculation by the chymotrypsin-like prostatic protease prostate-specific antigen, resulting in liquefaction of the… CONTINUE READING
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