Semen-Derived Amyloid Fibrils Drastically Enhance HIV Infection

  title={Semen-Derived Amyloid Fibrils Drastically Enhance HIV Infection},
  author={J. M{\"u}nch and Elke Ruecker and L. St{\"a}ndker and K. Adermann and C. Goffinet and M. Schindler and Steffen Wildum and Raghavan Chinnadurai and D. Rajan and A. Specht and G. Gim{\'e}nez-Gallego and P. S{\'a}nchez and Douglas M. Fowler and A. Koulov and J. Kelly and W. Mothes and J.-C. Grivel and L. Margolis and O. Keppler and W. Forssmann and F. Kirchhoff},
  • J. Münch, Elke Ruecker, +18 authors F. Kirchhoff
  • Published 2007
  • Medicine, Biology
  • Cell
  • Sexual intercourse is the major route of HIV transmission. To identify endogenous factors that affect the efficiency of sexual viral transmission, we screened a complex peptide/protein library derived from human semen. We show that naturally occurring fragments of the abundant semen marker prostatic acidic phosphatase (PAP) form amyloid fibrils. These fibrils, termed Semen-derived Enhancer of Virus Infection (SEVI), capture HIV virions and promote their attachment to target cells, thereby… CONTINUE READING
    The Surprising Role of Amyloid Fibrils in HIV Infection
    • 45
    • Highly Influenced
    • PDF
    A molecular tweezer antagonizes seminal amyloids and HIV infection
    • 52
    • PDF
    Semen-mediated enhancement of HIV infection is donor-dependent and correlates with the levels of SEVI
    • 124
    • PDF
    The Cationic Properties of SEVI Underlie Its Ability To Enhance Human Immunodeficiency Virus Infection
    • 162
    • PDF
    Gallic Acid Is an Antagonist of Semen Amyloid Fibrils That Enhance HIV-1 Infection*
    • 8
    • Highly Influenced
    • PDF


    Publications referenced by this paper.
    Stimulation of enveloped virus infection by beta-amyloid fibrils.
    • 32
    • Highly Influential
    • PDF
    HIV binding, penetration, and primary infection in human cervicovaginal tissue.
    • 141
    • PDF
    Brief but efficient: acute HIV infection and the sexual transmission of HIV.
    • 677
    • PDF
    Discovery and Optimization of a Natural HIV-1 Entry Inhibitor Targeting the gp41 Fusion Peptide
    • 217
    • PDF
    The role of sexually transmitted diseases in HIV transmission
    • 648
    • PDF
    Quantitation of human immunodeficiency virus type 1 infection kinetics.
    • 474
    • PDF
    Quantification of infectious HIV-1 plasma viral load using a boosted in vitro infection protocol.
    • 81
    • PDF