Semen-Derived Amyloid Fibrils Drastically Enhance HIV Infection

  title={Semen-Derived Amyloid Fibrils Drastically Enhance HIV Infection},
  author={Jan M{\"u}nch and Elke Ruecker and Ludger Staendker and Knut Adermann and Christine Goffinet and Michael Schindler and Steffen Wildum and Raghavan Chinnadurai and Devi Rajan and Anke Specht and Guillermo Gim{\'e}nez-Gallego and Pedro Cuevas S{\'a}nchez and Douglas M. Fowler and Atanas V. Koulov and Jeffery W Kelly and Walther Mothes and J C Grivel and Leonid Margolis and Oliver T. Keppler and W G Forssmann and Frank Kirchhoff},
Sexual intercourse is the major route of HIV transmission. To identify endogenous factors that affect the efficiency of sexual viral transmission, we screened a complex peptide/protein library derived from human semen. We show that naturally occurring fragments of the abundant semen marker prostatic acidic phosphatase (PAP) form amyloid fibrils. These fibrils, termed Semen-derived Enhancer of Virus Infection (SEVI), capture HIV virions and promote their attachment to target cells, thereby… CONTINUE READING
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