Semax and Selank Inhibit the Enkephalin-Degrading Enzymes of Human Serum

@article{Kost2004SemaxAS,
  title={Semax and Selank Inhibit the Enkephalin-Degrading Enzymes of Human Serum},
  author={Natalya V. Kost and Oleg Yu Sokolov and M V Gabaeva and Igor A. Grivennikov and Lyudmila A. Andreeva and Nikolay F. Myasoedov and Andrey A Zozulya},
  journal={Russian Journal of Bioorganic Chemistry},
  year={2004},
  volume={27},
  pages={156-159}
}
Dose-dependent effect of synthetic heptapeptides Semax (Met-Glu-His-Phe-Pro-Gly-Pro) and Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) on the enkephalin-degrading enzymes of human serum was demonstrated. The inhibitory effects of Semax (IC5010 μM) and Selank (IC5020 μM) are more pronounced than that of puromycin (IC5010 mM), bacitracin, and some other inhibitors of peptidases. Beside the heptapeptides, their pentapeptide fragments also possessed an inhibitory effect; tri-, tetra- and hexapeptide… 
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References

SHOWING 1-7 OF 7 REFERENCES
Hydrolysis and protection from hydrolysis of enkephalins in human plasma
TLDR
All enkephalin-degrading enzymes found in plasma are significantly inhibited by the endogenous substances present in this tissue, and the inhibition of the different classes of plasma enzymes by two of the three groups of endogenous substances is quite uniform, while one group of inhibitors appears specific to di peptidylpeptidases.
Biokhimiya mozga (Brain Biochemistry)
  • St. Petersburg: Izd. St. Petersb. Univ.,
  • 1999
Vyssh. Nervn. Deyat
  • 1998
Vyssh. Nervn. Deyat
  • Semax Selank
  • 1997
Opioidnye neiropeptidy, stress i adaptatsionnaya zashchita serdtsa (Opioid Neuropeptides, Stress and Adaptation Protection of Heart), Tomsk: Izd. Tomsk
  • 1994