Semax and Selank Inhibit the Enkephalin-Degrading Enzymes of Human Serum

  title={Semax and Selank Inhibit the Enkephalin-Degrading Enzymes of Human Serum},
  author={Natalya V. Kost and Oleg Yu Sokolov and M V Gabaeva and Igor A. Grivennikov and Lyudmila A. Andreeva and Nikolay F. Myasoedov and Andrey A Zozulya},
  journal={Russian Journal of Bioorganic Chemistry},
Dose-dependent effect of synthetic heptapeptides Semax (Met-Glu-His-Phe-Pro-Gly-Pro) and Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) on the enkephalin-degrading enzymes of human serum was demonstrated. The inhibitory effects of Semax (IC5010 μM) and Selank (IC5020 μM) are more pronounced than that of puromycin (IC5010 mM), bacitracin, and some other inhibitors of peptidases. Beside the heptapeptides, their pentapeptide fragments also possessed an inhibitory effect; tri-, tetra- and hexapeptide… 
Degradation of the ACTH(4-10) analog Semax in the presence of rat basal forebrain cell cultures and plasma membranes
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Study of the relationship between analgesic activity and structure of synthetic melanocortin analogs
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Physiological Effects of Selank and Its Fragments
A comparative analysis of the structural and functional regularities of the effects of Selank and its fragments was performed, and it is assumed that the Selank effect on the network of cascade processes of peptides and mediators is carried out through enkephalin, the key player of this system.
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Influence of the conditions of deuterium and tritium labeling of His–Phe–Arg–Trp–Pro–Gly–Pro oligopeptide on the isotope exchange efficiency
Deuterium- and tritium-labeled His–Phe–Arg–Trp–Pro–Gly–Pro [ACTH(6–9)PGP] samples were prepared. The formation of isotopomers depending on the reaction conditions was monitored by mass spectrometry.
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Hydrolysis and protection from hydrolysis of enkephalins in human plasma
All enkephalin-degrading enzymes found in plasma are significantly inhibited by the endogenous substances present in this tissue, and the inhibition of the different classes of plasma enzymes by two of the three groups of endogenous substances is quite uniform, while one group of inhibitors appears specific to di peptidylpeptidases.
Opioidnye neiropeptidy, stress i adaptatsionnaya zashchita serdtsa (Opioid Neuropeptides, Stress and Adaptation Protection of Heart), Tomsk: Izd. Tomsk
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Vyssh. Nervn. Deyat
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