Semax and Selank Inhibit the Enkephalin-Degrading Enzymes of Human Serum

  title={Semax and Selank Inhibit the Enkephalin-Degrading Enzymes of Human Serum},
  author={Natalya V. Kost and Oleg Yu Sokolov and M V Gabaeva and Igor A. Grivennikov and Lyudmila A. Andreeva and Nikolay F. Myasoedov and Andrey A Zozulya},
  journal={Russian Journal of Bioorganic Chemistry},
Dose-dependent effect of synthetic heptapeptides Semax (Met-Glu-His-Phe-Pro-Gly-Pro) and Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) on the enkephalin-degrading enzymes of human serum was demonstrated. The inhibitory effects of Semax (IC5010 μM) and Selank (IC5020 μM) are more pronounced than that of puromycin (IC5010 mM), bacitracin, and some other inhibitors of peptidases. Beside the heptapeptides, their pentapeptide fragments also possessed an inhibitory effect; tri-, tetra- and hexapeptide… 
Degradation of the ACTH(4-10) analog Semax in the presence of rat basal forebrain cell cultures and plasma membranes
The approach applied allows analyzing physiologically active peptide concentrations in biological tissues and degradation pathways of peptides in the presence of targets of their action.
Study of the relationship between analgesic activity and structure of synthetic melanocortin analogs
The peptide analgesic effect was observed after the replacement of the N-terminal methionine with lysine or after the attachment of glucuronic acid to the methions, while the peptide with glycine instead of the methionines had no effect on pain sensitivity.
Physiological Effects of Selank and Its Fragments
A comparative analysis of the structural and functional regularities of the effects of Selank and its fragments was performed, and it is assumed that the Selank effect on the network of cascade processes of peptides and mediators is carried out through enkephalin, the key player of this system.
Natural and hybrid ("chimeric") stable regulatory glyproline peptides.
Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission
The data obtained indicate that Selank is characterized by its complex effects on nerve cells, and one of its possible molecular mechanisms is associated with allosteric modulation of the GABAergic system.
A New Generation of Drugs: Synthetic Peptides Based on Natural Regulatory Peptides
The results of research aimed at studying the influence of these peptides on the transcriptome of brain cells are presented, which were the bases for the creation of new drugs that are used effectively in the treatment of various diseases of the nervous system.
New development in the tritium labelling of peptides and proteins using solid catalytic isotopic exchange with spillover-tritium
The reaction ability of amino fragments in HSCIE was shown to depend both of their structures and on the availability and the mobility of the peptide chain, which completely retained their biological activity.
Influence of the conditions of deuterium and tritium labeling of His–Phe–Arg–Trp–Pro–Gly–Pro oligopeptide on the isotope exchange efficiency
Deuterium- and tritium-labeled His–Phe–Arg–Trp–Pro–Gly–Pro [ACTH(6–9)PGP] samples were prepared. The formation of isotopomers depending on the reaction conditions was monitored by mass spectrometry.
Expression of in fl ammation-related genes in mouse spleen under tuftsin analog
This poster presents a probabilistic procedure for determining the carrier and removal of polypeptide-like particles from the DNA of animals using a simple, straightforward, and straightforward procedure.


Hydrolysis and protection from hydrolysis of enkephalins in human plasma
All enkephalin-degrading enzymes found in plasma are significantly inhibited by the endogenous substances present in this tissue, and the inhibition of the different classes of plasma enzymes by two of the three groups of endogenous substances is quite uniform, while one group of inhibitors appears specific to di peptidylpeptidases.
Biokhimiya mozga (Brain Biochemistry)
  • St. Petersburg: Izd. St. Petersb. Univ.,
  • 1999
Vyssh. Nervn. Deyat
  • 1998
Vyssh. Nervn. Deyat
  • Semax Selank
  • 1997
Opioidnye neiropeptidy, stress i adaptatsionnaya zashchita serdtsa (Opioid Neuropeptides, Stress and Adaptation Protection of Heart), Tomsk: Izd. Tomsk
  • 1994